bringing chemistry to life by Thermo Fisher Scientific
According to the second law of thermodynamics, the entropy of a system will always increase. For a layperson, this means that all things must come to pass and nothing lasts forever. Since no person or thing can evade the laws of physics, this also applies to Bringing Chemistry to Life.
Join us for this look into materials chemistry, developed under the guiding principles of sustainability and a systems approach.
Some debate that synthetic organic chemistry strategies have become stale, but Dr. Todd Hyster of Princeton University's Hyster Lab disagrees.
Early in her career, Dr. Jessica Reiner realized that she cared more about ensuring the accuracy of the measurements she was making than making the measurements themselves. This realization, combined with experience in working with PFAS, led to her current role as Research Chemist at the National Institute of Standards and Technology (NIST).
Bioconjugation of antibodies to drugs via chemical linkers is how antibody drug conjugates (ADCs) are made. We’re joined by Matt Giese, Senior Scientist at Vector Laboratories, who talks us through the complex chemistry options and biodesign considerations that have to be considered and balanced when making a successful ADC.
We're diving into an important topic: the representation of women in STEM careers. Despite making up about 50% of the population, women hold only around 34% of STEM positions, with even fewer—approximately 25%—in the chemicals industry. Why is this the case, and what can be done to change it?
Strap in for this charged up conversation. Battery chemistry is a topic we’ve touched on before and is one we’ve committed to exploring further in this season. This conversation with Dr. Heather Platt, Co-Founder and Chief Battery Scientist at Platt Engineering Solutions, takes us on an expert-guided tour of battery chemistry.
Join our host, Dr. Paolo Braiuca, as he chats with some of the most fascinating scientists around the globe doing trailblazing work in a variety of fields and industries. Learn about their personal stories, notable contributions, and the enthusiasm for discovery that unites them all. This is a podcast for anyone who wants to learn more about science and the brilliant minds advancing it.
Anyone that’s followed this podcast will know that Paolo’s final question to each guest is, “What advice would you like to share with younger scientists just starting their career?” Here, our guest, Dr. Monte Helm, professor of chemistry at Metropolitan Community College in Kansas City, shares advice that he clearly lives by, which is, “… be flexible ii your career and follow what you think you’ll be passionate about.”
Most of us don’t grow up across the street from a chemistry building or know from an early age that we want to be a scientist, but Alan Dyke, VP of Business Development for ProChem, Inc. (CTO of Boulder Scientific Company at the time of the interview) did and became a chemist. Dr. Alan Dyke, former colleague, and friend of Paolo’s, shares his career path and discusses the history and current state of the field of catalysis.
Bringing Chemistry to Life is as much about the people behind the science as it is about the science itself. We’ve been remiss in sharing a bit more about the creator and host! In this unique episode we flip the script and move Paolo from the host chair to the guest chair to hear his story.
With four seasons under our belt, we’ve heard some amazing stories about how our guests have found, or often “stumbled” into, their careers in science. We’ve also had many conversations where past guests have passionately discussed the importance of their early career teachers as well as what teaching does for them in their current careers. This conversation is squarely centered on these two topics, with a good dose of photochemistry mixed in too.
After realizing at a young age that rock and roll might be a better hobby than a career, our guest chose chemistry and chromatography as his path, and he’s rocked that career choice!
Protein biology has always been grounded in the relationship between structure and function but how we determine structure has changed dramatically. While it’s still common to crystallize a protein for X-ray diffraction and then back calculate its structure, supercomputing-powered, AI-driven tools have revolutionized approaches to getting a protein structure and engineer proteins for uses such as biocatalysis. Amazing right, but how? By using wet lab data to train and then compute, protein structure based on their sequence alone, which is why talking with this episode’s guest is so interesting.
Electricity undeniably changed the world and enabled countless other technologies. Now, via storage and mobile access to electrical energy, batteries are positioned to further enable us as a species. So, it is the perfect time to get to know battery technology innovator and entrepreneur, Dr. Simon Engelke, Founder and Chair of Battery Associates, as he shares his passion for sustainable battery innovation. Any battery enthusiast will feel recharged by this electrifying conversation about the past, present, and future of battery technology.
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the guest content sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the guest content sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and guest content and resources, which includes links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the video version of this episode via https://youtu.be/LtWghIdoeLo.
Over 80,000 Laboratory Chemicals are now consolidated under the Thermo Scientific brand. This unified portfolio is now available at thermofisher.com/chemicals along with everything else you need to focus on your science.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Great scientists look at the world around them, identify problems and think about how their area of expertise can provide a solution. This is what Jessica Ray does. In her native St. Louis, she experienced regular urban flooding and grew up familiar with the problem of managing urban wastewater. When, later in life, her studies took her to California, she experienced the opposite problem of severe droughts. This is how she became interested in urban water and started applying her chemical engineering skills to deal with the problem of contaminants, such as PFAS, in urban waste waters.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.
For decades the pharmaceutical industry has synthesized millions of molecular entities in the pursuit of novel biological activities. These huge compound libraries have always been considered a treasure trove of potential new drugs for a plethora of new therapeutic targets. With the huge progress in laboratory automation and high-throughput technology over the last decade, library screening remains a key drug discovery strategy. The size of these libraries and their handling present however multiple challenges, starting from the synthesis and screening speed, storage space, and annotation required when working with Singleton compounds. A clever alternative finds inspiration from biology and leverages the DNA information storage power. This is known as DNA Encoded Libraries, or DELs. Dr. Katelyn Billings is a pioneer of this technology that offers a number of advantages, starting from the possibility of working on the nanoscale in as little as a few microliters to make and screen millions of molecules as a pool. In this episode we learn about how DELs work and discuss their advantages, challenges and the promise of combining data from DEL screens with machine learning to disrupt modern drug discovery.
Life is the result of an incredibly complex mix of chemical reactions, all happening at the same time, influencing each other. These apparently chaotic and incomprehensible systems are elegantly regulated at organ, tissue and even cellular and sub-cellular level. Most of these chemical phenomena are not fully understood and the scale and complexity of the micro-environment where they happen often prevent scientific observations without perturbing them. This is where out-of-the-box chemical thinking can make a difference, and this is what Dr. Peng Zou has dedicated his research efforts to. Smart use of chemical tags can allow us to literally visualize chemical phenomena inside the cell as they happen, using relatively straightforward technologies such as fluorescence microscopy. One reaction at a time, Peng’s team is developing detailed cellular maps and achieving significant advances in the comprehension of the cell’s chemical machinery. This episode is masterful example of how chemistry can advance biological knowledge.
Theoretical chemistry is one of those subjects that can intimidate even the most passionate experimental chemist. Complex theories rooted in super-advanced mathematics to model a chemical bond length are not everyone’s cup of tea. Yet it does not have to be like that and it takes brilliant minds like Brenda Rubenstein’s to make it so elegantly obvious. Brenda and Paolo’s discussion is as approachable as it gets; a surprisingly eye-opening discovery of how theory can have profound effects on experimental practice. Brenda talks through her efforts in finding the right balance between molecular simulations’ theoretical rigor and their practical utility, and opening the door to her incredible creative thinking and courage in pursuing disruptive ideas. Her novel paradigm for the computer of the future, where chemistry is used to achieve massive increases in data storage density compared to traditional semiconductor technologies, represents truly out-of-the-box. As if all this wasn’t enough, we also find a brilliant example of social responsibility in Brenda’s commitment to change lives of children from low-income background through facilitating access to STEM education. An unmissable episode.
Since the elucidation of the DNA structure by James Watson and Francis Crick in 1951, the importance of understanding the three-dimensional structure of biomolecules has become obvious. Over the last few decades scientists have resolved the structure of thousands of complex biomolecules enabling incredible innovations in drug design, biological and medical sciences. X-Ray crystallography has been the key technique, but in recent years Nuclear Magnetic Resonance (NMR) has emerged as an additional, complementary approach. Dr. Loren Andreas explains to us how NMR has grown to be the technology of choice as it has expanded its field of application from liquid solutions to condensed systems. The discussion is a surprising discovery of how progress in engineering and instrument design has completely changed the landscape in structural biology. Modern NMR allows scientists to study molecules in complex systems, simulating more closely their natural environment, including interaction between them. This episode offers an exciting glimpse of the future, through a few examples from today’s science.
80% of waste water gets discharged untreated, which causes some of the most urgent environmental issues facing our planet. However, Dr. William Tarpeh, nominated as one of The Root 100's most influential African Americans, views waste water is an incredible resource that contains many valuable components and represents an untapped economic opportunity in our world of finite resources.
Common phenomena, observed by most in their daily experience, can be surprisingly misunderstood and even mysterious! Genuine curiosity, an open mind, and good dose of creativity are the necessary ingredients for the most exciting scientific discoveries. This is the take-home message of our fascinating discussion with Dr. Lauren Zarzar, who studies microscale systems and their macroscopic effects. We find out what is behind the iridescence at the air-water interface, how this can be reproduced and controlled with many different types of emulsions, and how it could be used in novel paints and display technologies. We also discuss 3D printing at the nanoscale using lasers and how this can revolutionize materials science. The work of Dr. Zarzar is yet another great demonstration of how great science happens at the interface between different disciplines, with chemistry usually being one of them.
If you thought chemistry is basically just boiling stinky mixtures in a flask, this is the episode for you. There is no better demonstration for how chemistry is foundational to practically all sciences and technologies. What Dr. Tina Li does at CMC Materials is finding new ways to ensure semiconductor layers in electronic components manufacturing are as smooth as possible, to allow the deposition of as many layers as possible on a single wafer. This is the key to enable increased complexity and computational power for all electronic devices.
If you thought a career in science means spending your best years in a dark laboratory for long, boring hours doing routine experiments, think again! Dr. Cora Young, from York University in Toronto, does a significant part of her environmental chemistry work in the field. From measuring air quality in residential and business spaces, to going high altitude on airplanes, or doing measurements in forests and even in the Arctic.
Polymer chemistry has been one of the main disruptive forces in the last few decades, having a profound impact on materials used in all applications, enabling new technologies and profoundly impacting everyone’s life. Polymers are at the core of modern material science and despite having generated some concerning environmental challenges, it’s hard to imagine a future without them.
Human milk provides both nutritional and non-nutritional components tailored to the specific need of the infant at all phases of growth. It is a wonderful example of personalised medicine and diet and its complexity is only partially understood. The oligosaccharides contained in breastmilk have only recently emerged as potent pro- and anti-biotics and they are proven to have effects on several other physiological mechanisms and biological pathways, such as the immune system.
